BeskrivelseUiB - Knowledge that shapes societyThrough robust and close interaction with the world around us – globally, nationally and locally – we shall be instrumental in building a society based on knowledge, skills and attitudes.Do you want to take part in shaping the future?ResearcherAt the Faculty of Medicine, Department of Clinical Medicine, in the Renal Research Group, a full-time (100 %) position as researcher is available for a period of three (3) years. The position is part of the project “Single Cell Data-derived European Study for Personalised Management of Chronic Kidney Disease (CKD) in Children and Adolescents”, financed by the Research Council of Norway. The main research interest of the Renal Research group consists of the advanced management of chronic kidney diseases. Expected starting date is negotiable, but no later than fall 2024.About the project/work tasks:Background: Minimal-change disease (MCD) as our proxy of CKD reflects a renal pathology primarily affecting glomerular podocytes. MCD represents the most frequent chronic kidney disease (CKD) in children and adolescents, leading to nephrotic syndrome and potentially to kidney failure. Conventional treatment of the disease involves steroid therapy. However, these children and adolescents may be primary or become secondary resistant to steroids. Unfortunately, the initial diagnostic kidney biopsy has no intrinsic prognostic power.Main objective: Improve and personalize the management of MCD in children and adolescents by identifying glomerular podocyte markers to supplement the diagnostic kidney biopsy with added prognostic value and to subsequently assess/predict non-invasively the treatment response.Specific objectives: 1. Get prognostic MCD markers through single cell podocyte RNA sequencing and proteomics from archival kidney biopsies of the Norwegian Kidney Biopsy Registry with validation in external cohorts from UK and Sweden. 2. Detect identified renal biopsy-derived markers in liquid biopsies, such as blood and/or urine samples, from Norwegian, UK and Swedish MCD cohorts. 3. Develop statistical machine learning methods integrating liquid biopsy markers with clinical (e.g., blood pressure), and laboratory (e.g., serum creatinine, albuminuria) parameters to get a non-invasive prognostic MCD monitoring test. 4. Prepare prospective test validation in a multicenter clinical trial.Project organization: The project is hosted by the University of Bergen (UiB) at the Renal Research group of the Department of Clinical Medicine and organized in national as well as international collaboration with the University of Bristol, Bristol, UK, and the Karolinska Institutet, Stockholm, Sweden. The project is organized into four interactive work packages.Tasks: The researcher will join the active Renal Research Group with professor Hans-Peter Marti as principal investigator (PI), and with Professor Camilla Tøndel and Øystein Eikrem, PhD, as co-PI. The researcher will work at the introduction and application of single cell mRNA sequencing and proteomics from archival kidney biopsies as wells as validation of key results in liquid biopsies. Participation in development and application of statistical machine learning methods is optional.Qualifications and personal qualities:The applicant must hold a relevant Norwegian PhD or equivalent doctoral degree.Extensive experience in the application of omics-based technologies in addition to at least basic knowledge in respective data interpretation.Solid knowledge in biostatistics and basic knowledge in epidemiology.Broad practical experience with the use of basic laboratory techniques, such as cell cultures, PCR, Western blot, and immunohistochemistry (IHC).Documentation of prior productivity in the form of scientific publications, abstracts, and conference proceedings.You will be expected to work independently and in a structured manner, be self-motivated, have good collaborative skills and have a great work capacity and enthusiasm for research.Experience with supervision and pedagogical competence as well as willingness/competence to teach medical students is a strong advantage.The applicant must be experienced in counseling, teaching, writing manuscripts and preferentially also grant applications.Personal skills, including abilities to work independently and cooperate within a research group will be evaluated.The applicant must be motivated and responsible, and also have a great work capacity and enthusiasm for research.The candidate must be fluent in written and oral English as well as be willing to learn Norwegian if needed.Experience with international collaboration is an advantage.We can offer:Exciting development opportunities as part of your role in a strong professional environmentSalary NOK 624 500 (code 1109, pay grade 64), specialist NOK 646 000 (code 1109, pay grade 66) gross p.a. for a fulltime position. In the case of a highly qualified applicant, a higher salary may be considered.Enrolment in the Norwegian Public Service Pension FundGood welfare benefitsYour application must include:A brief letter of application stating your motivation for the position, why you are applying and why this position is perfect for you.An overview of your education and work experience (CV).Witnessed copies of diplomas and relevant certificates (applicants with education from other countries than Norway must enclose diplomas in both the original language and authorized translations).Publications and academic work (max 10 in PDF) and a list of these.Your PhD thesis (in PDF)Two references (name and contact information)It is very important that each of the scholarly works on which the committee should place special emphasis, is attached in its entirety.The following premise forms the basis for the post as research scientist:The researcher will be a member of the research group of which the topic/project belongs to.The salary shall if possible be 100 % covered by external financing.The researcher shall actively contribute to attract external funding to the research project, both for her/his own position and other positions, from the Research Council of Norway, EU and other sources.The researcher is expected to have her/his research activity financed by the project of the researcher and the projects of the associated research group.The Head of Department may allocate work for the Researcher related to specific research projects.The researcher may participate in committee work and other administrative tasks within the University of Bergen.The researcher has no teaching duties, but is expected to supervise master students and PhD candidates when this is a natural part of the research activity of the research group.The researcher may apply for competence promotion according to the regulations for promotions.The basis for the position ceases if no further project funding and new law on state officials etc. on dismissal and preferential rights will be applied to permanent employees.General information:Further information about the position pcan be obtained from:  Professor Hans-Peter Marti, hans-peter.marti@uib.no, phone: +47 940 30 929, or post doctor Øystein Eikrem, PhD, oystein.eikrem@uib.no; phone +47 454 46 008.«UiB must follow Norway’s export control regulations when processing applications for this position.»The state workforce shall reflect the diversity of Norwegian society to the greatest extent possible. People with immigrant backgrounds and people with disabilities are encouraged to apply for the position.The University of Bergen applies the principle of public access to information when recruiting staff for academic positions.Information about applicants may be made public even if the applicant has asked not to be named in the list of persons who have applied. The applicant must be notified if the request to be omitted is not met.For further information about the recruitment process, click here.

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