BeskrivelseJob descriptionApplications are invited for a three year position in a Research Fellowship as PhD Candidate in transplantation medicine to be based at The Norwegian PSC Research Center (NoPSC), Institute of Clinical Medicine, University of Oslo.Primary sclerosing cholangitis (PSC) is a chronic liver disease for which no current therapy exists and which therefore is the most important indication for liver transplantation in Norway. NoPSC is a world-leading research center for the chronic liver disease primary sclerosing cholangitis (PSC). The center counts 35-40 employees from all over the world, covering all aspects of PSC-related research, from basic genomic and experimental studies to clinical research and clinical trials. (https://www.med.uio.no/klinmed/english/research/groups/primary-sclerosing-cholangitis/index.html).In our previous studies, we have identified a disease causing mutation for PSC and observed that mice with a similar mutation are more vulnerable to persistent biliary inflammation. This observation cannot be fully explained by known mechanisms related to immune resistance or regulation. Therefore, we now seek a highly motivated and creative co-worker to further explore the molecules involved in disease tolerance and tissue adaptation.More about the positionThe fellowship period is 3 years. The project aims to discover novel protective factors against persistent inflammation, utilizing unique mouse models. The work will be conducted in the experimental group at NoPSC, led by Professor Espen Melum, equipped with relevant techniques such as high-dimensional flow cytometry, 3D cell cultures, single-cell RNA sequencing, and spatial multi-omics. The findings are expected to have significant translational potential, and aims to contribute to the development of efficient treatment for PSC. The successful candidate must be admitted to the PhD program at the Faculty of Medicine, University of Oslo with Researcher Xiaojun Jiang and Professor Espen Melum as key supervisors.The research fellow must take part in the University’s/ Faculty’s/ Department’s approved PhD program and is expected to complete the project within the set fellowship period. The main purpose of the fellowship is research training leading to the successful completion of a PhD degree.Qualification requirementsapplicants must be a cand.med/MD or hold a Master’s degree or equivalent in immunology or molecular biologyfluent oral and written communication skills in Englishexperience with mouse experiments (Felasa C certificate) or willingness to be trained with animal researchexperience with relevant experimental techniques to study cellular immune responses: cell isolation, cell culture, flow cytometry, and immunohistochemistryPersonal skillsIn the assessment of applicants, the committee will focus on the candidate’s scientific and personal abilities to accomplish both the research education and the research project.personal suitability and motivation for the positionwell organized with high working capacity and productivityflexibility and ability to work in a team as well as independentlyWe offersalary NOK 532 200 – 575 400 per annum depending on qualifications in a position as PhD Research fellow, position code 1017attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activitiesHow to applyThe application must includecover letter statement of motivation and research interestsCV (summarizing education, positions and academic work)copies of educational certificates (academic transcripts only)evt. documentation of english proficiencya complete list of publications and academic workslist of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)The application with attachments must be delivered in our electronic recruiting system, please follow the link: “Apply for this job”. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).When evaluating the application, emphasis will be given to the applicant’s academic and personal prerequisites to carry out the project. Applicants may be called in for an interview.Formal regulationsPlease see the guidelines and regulations for appointments to Research Fellowships at the University of Oslo.No one can be appointed for more than one PhD Research Fellowship period at the University of Oslo.According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.The appointment may be shortened/given a more limited scope within the framework of the applicable guidelines on account of any previous employment in academic positions. The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. Furthermore, we want employees with diverse professional expertise, life experience and perspectives.If there are qualified applicants with disabilities, employment gaps or immigrant background, we will invite at least one applicant from each of these categories to an interview.Contact informationSenior researcher Xiaojun Jiang, PhD, e-mail: jiang.xiaojun@medisin.uio.no Phone 23073628Professor Espen Melum, PhD, MD, e-mail: espen.melum@medisin.uio.no Phone 91780732

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